Bioflu Studies: Star Anise
Bioflu | Abstract 6
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Cancer chemopreventive activity of phenylpropanoids and phytoquinoids from Illicium plants.
© Cancer Lett. 2004 Oct 28;214(2):165-9. Itoigawa M, Ito C, Tokuda H, Enjo F, Nishino H, Furukawa H. Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya 468-8503, Japan. itoigawa@tokaigakuen-c.ac.jp
In our joint project involving search of anti-tumor promoters from natural plant sources, six phenylpropanoids and seven phytoquinoids isolated from three Illicium plants (Illiciaceae) were tested for their inhibitory activities against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All tested compounds showed inhibitory activity against the EBV-EA activation even at 1 x 10mol ratio, and the inhibitory activity of their compounds was found to be more than that of beta-carotene. Two phenylpropanoids having prenyl group, 4-allyl-2-methoxy-6-(3-methyl-2-butenyl)phenol (3) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol (4), showed more potent activities as anti-tumor promoters (IC50 224 and 217 mol ratio/TPA, respectively). The presence of a prenyl moiety in the phenylpropanoids plays an important role in anti-tumor promoting activity as xanthone, coumarin and flavonoid previously reported. This investigation indicated that prenylated phenylpropanoids might be valuable as potential cancer chemopreventive agents.
Note: Star anise (Illicium verum) is an active ingredient of Bioflu.
The information contained above is protected by copyright. Wellness Plus has, where appropriate, obtained the permission of the copyright owner to publish the articles on this site. This permission does not convey to any third party.